Abstract:
Introduction:- Combination dosage forms are gammg approval in global markets in
increasing numbers. Combining two or more drugs result in a product that is more
effective than its separate components. Objective: - To investigate the combined effect of diclofenac and ranitidine together as
enteric coated pellet form which is compressed into tablet formulation.
Methods: -I this study an innovative formulation have been proposed that includes
diclofenac and ranitidine together as enteric coated pellet form which is compressed into
tablet formulation. The literature contains numerous reports and experiments that had been studied on the
combination preparation of diclofenac and ranitidine together in a single formulation. If
this formulation is prepared it can be effectively use in the therapy of NSAID-induced
gastrointestinal disorders and will increase patient compliance. The method that has been proposed for pellet manufacture is powder layer technique.
Initially two individual enteric coated pellets of ranitidine and diclofenac must be made
and then they should be compressed together by direct compression method. The
proposed formulations are to be evaluated by performing the dissolution and
disintegration analysis. Results: - It is possible to combine diclofenac and ranitidine together as enteric coated
pellet form which is then compressed into a tablet.
Conclusions: - Compression of coated pellets is a challenging task necessitating the
optimization of various formulations and process variables. In this study how two drugs
in pellet form can be presented in a more convenient dosage form has been proposed.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.