Abstract:
The aim of the study is to design, formulation and evaluation of sustained release diclofenac
tabler, prepared by direct compression method. The polymers played vital role in the designing
of SR product. In this study, six formulations (F-l - F-6) were prepared by using two different
hydrophilic polymers Methocel K15M Premium and Methocel KlOO LV CR Premium which
were acted as matrix. Physical criteria of formulations (F-l - F-6) like loose bulk density
,O.221±O.02 to O.521±O.Ol), tapped bulk density (O.327±O.02 to O.457±O.03), compressibility
mdex (11.15±O.03 to 13.35±O.02\ total porosity (26.19±O.04 to 34.56±0.01), angle of repose
21.53±0.01 to 29.36±O.0l), hardness (3.19±0.01 to 4.35±0.03), friability (0.0 to O.12±0.02),
thickness (4.19±0.12 to 4.90±O.03) and weight variation tes1 (1.132±O.02 to 2.903±O.23) were
evaluated for the formulations (F-l - F-6). The drug content in the proposed formulations (F-I-F-6) were 47.61%, 47.61%,43.63%,43.63%,43.63%, and 48% respectively and drug-polymer ratios
11 :5,3:4,2:5,4:3,3:3 and 3:5) respectively has directly influenced steady state drug release from
the matrix. Formulations (F-3 and F-6 ) showed standard release in vitro than any other
in buffer medilLtn for 8 hours using USP reference dissolution apparatus. On the
Other hand formulations (F-l, F-2, F-4, and F-5) did not fulfill the official drug release for 8
hours. The drug release profile was extrapolated by zero-order release kinetics, first order
release kinetics, Higuchi release kinetics, and Hixson-Crowell release kinetics. This study gives
idea on how the release pattern of granules and tablets altered upon the changing of polymer
ratIo .
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.