Abstract:
Typhoid fever is a serious and potentially fatal bacterial infection. It can cause symptoms of
fever, abdominal pain and constipation. If they are not treated, symptoms can rapidly get worse
and lead to serious complications. It is a serious health problem in the African and eastern parts
of Asia especially in areas with poor sanitation and no access to clean water, such as India and
most of Africa. The signs and symptoms playa major role in the determination of the disease,
although it is only confirmed by a proper and acute diagnosis. But in true sense, an appropriate
detail of sign and symptoms gives a clear indication to the diagnosis and ultimately treatment of
Typhoid fever. Thus a specific, distinctive, clear and meaningful study on the sign and symptoms
is vital in the treatment of the disease. The study was a case-control one conducted at the general
wards ofICH (Institute of Child Health) and SSF (Shishu Shastho Foundation) to figure out the
common sign and symptoms among the Typhoid patients. To conduct the study, a structures
questionnaire was used as data source and a total of 112 Typhoid and Non-Typhoid patients were
taken into consideration. It was interesting to find out that among the Typhoid patients, 59%
were male and 41 % were female, meaning that the disease is much more prone to male. It was
also found that the age group <3 years (40%) was the dominant group followed by 3-<6 years
130%),6-<9 years (22%), and 9-12 years (8%).Vomiting, abdominal pain, loose motion and
constipation etc were among the leading signs and symptoms in Typhoid ferver according to the
study. It signifies that the gastro-intestinal sign and symptoms are prevalent in the disease. But a
significant finding obtained during the ANC calculation and Neutropenia measurement.ANC of
the group (0-5x 103
) was dominant in Non-Typhoid patients which is not usual. Again,
~eutropenia was also more prone to the Non-Typhoid patients rather than the Typhoid patients,
which may be due to the exclusion of the count of the band forms ofneutrophils in the complete
blood count (CBC) differential or genetic or regional differences. The study result also showed
that maximum (61%) no. of Typhoid patients came up with two sign and symptoms. However, it
is clear from the study that an accurate and specific study of the sign and symptoms and ANC is
necessary and facilitates the diagnosis and treatment of Typhoid fever.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.