Abstract:
Background: The purpose of this research work was to determine the in vitro release
profile kinetics of four brands (Sultolin, Vento lin, Brodil and Salbutal) of salbutamol
tablet of Bangladesh.
Method: Ten tablets from each brand were taken to perform thickness test, weight
variation test, friability test, and hardness test individually. Another two tablets from each
brand were taken to do the dissolution test. Thickness tests were done using the Vernier
Calipers. Weight variation tests were done using electronic weighing balance. Friability
tests were done in the Roche Friabilator and hardness tests Monsanto Hardness Tester.
The dissolution test was performed using dissolution tester (RC6, Vanguard
Pharmaceuticals, USA). After dissolution test of the four brands absorbances were
compared with the standard solution of crude salbutamol sulphate.
Result: The average thickness of Sultolin, Ventolin, Brodil and Salbutal were found
8.l7mm, 8.42mm, 9.77mm and 6.32mm respectively. The % friability of Sultolin,
V entolin , Brodil and Salbutal were 0.37, 0.17, -0.14, -0.10 respectively. The mean
hardness values of Sultolin, Vento lin, Brodil and Salbutal were 10.007N, 11.64N, 14.72
~ and 13.04N respectively. Average weights of Su1tolin, Ventolin, Brodil and Salbutal
\!Jere found 0.17103gm, 0.20097 gm, 0.19688gm and 0.10086gm respectively. No brand
met the absorbance of standard salbutamol sulphate.
Conclusion: After conducting all the tests to determine various parameters, it has been
found that, release profile kinetics of Sultolin, Ventolin, Brodil and Salbutal differed a lot
from each other and also from the standard.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.