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Study of Sustained Release Matrix of Diclofenac from Hydrophilic Polymer

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dc.contributor.author Rayhan, A.K.M.
dc.date.accessioned 2019-02-26T09:46:31Z
dc.date.available 2019-02-26T09:46:31Z
dc.date.issued 3/28/2010
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2957
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract In the entitled study, an effort has been delivered to develop once daily-sustained release matrix tablets of diclofenac. The design of Diclofenac SR tablet (NSAID), a cyclooxygenase inhibitor is to achieve more patient compliance. To prepare tablets of our desired formulation direct compression method were followed which easier and less time is consuming. Since the study concerns with the development of sustained release matrix tablet, a high viscosity and molecular weight (MW>300) of polymer were used. Several ratios ofmethocel K15 M CR & KlOO LVCR (hydrophilic polymer) were used as rate retarding materials. Before compressing the tablets, the granules of different proposed formulations (F-I to F -9) were e\'aluated for LBD (0.40-0.435 glml), TBD (0.625-0.69 glml), % Compressibility Index 430.4-40.03), Total Porosity, Angle of Repose (46.85°-68.96°), Hausner Ratio (1.44-1.90) md % Total Porosity (20.35-30.87 %). The tablets were subjected to thickness, Diameter, ~ght variation test, hardness and friability test. Depending upon the values of angle of repose and % compressibility index, the granules show poor flow properties. While according ID banner ratio formula F-8 (1.44) shows moderate flow property. In the designing of trained release product, the physical evaluations alone do not indicate a good % release of en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00031
dc.subject Diclofenac, Sustained release, Matrix tablets, Hydrophilic polymer, Direct compression. en_US
dc.title Study of Sustained Release Matrix of Diclofenac from Hydrophilic Polymer en_US
dc.type Thesis en_US


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