Abstract:
The study was done to evaluate six fonnulations of Diclofenac Sodium SR 12H
incorporated with two different polymers ( Methocel K 15 MCR & Methocel 1 00 LV
CR). The polymers played an important role upon the % drug release. The
fonnulations (F-l to F-6) polymer ratio was (1:5, 3:4, 2:5, 4:3, 3:3, 3:5). The
fonnulations F-3 & F-6 fulfill the official requirements in 2 hour is simulated acidic
(PH 1.3) and 8 hour in buffer (PH 6.8). Dissolution was done by USP reference
dissolution apparatus .The physical evaluation such as bulk density, compressibility
index, angle of repose, total porosity, hausner ratio, hardness & friability test,
thickness, weight variation test was also done. In vitro drug release profile was extra
cloated by drug release kinetics Zero order and First order equation.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.