In Vitro Antimicrobial Susceptibility Test of Doxin®&Doxysina® (OPSONIN & IBNSINA) Brands of Bangladesh

Abstract

Objective: The study is carried out to evaluate the antimicrobial susceptibility test of two different brands of Doxycycline available in the market of Bangladesh. Doxin® 100mg and Doxysina® 100mg were selected for the study that were manufactured by Opsonin Pharmaceutical Co. Ltd. and Ibnsina Pharmaceutical Co. Ltd respectively. This study also helped us to investigate whether these brands were manufactured according to the standard specification or not by the companies. Method: Two different brands of antibiotic were collected from the local market of Bangladesh. 200μg, 250μg, 300μg, 350μg, 400μg doses were selected for both of the brands and antimicrobial test was carried out according to the Kirby-Bauer disc diffusion method to determine the zone of inhibition against four different microorganisms (S. pneumoniae, Staphylococcus aureus, H. influenzae and E. coli). Results: From the experiment it was observed that all the capsules of doxycycline of two brands in different concentrations showed significant zone of inhibition and that were approximately similar to that of the standard. Conclusion: The studied two brands of doxycycline were capable to inhibit the growth of susceptible microorganisms. Further investigation need to be carried out to determine the quality parameters of the two brands of doxycycline.