Abstract:
Neonatal septicemia is a significant cause of morbidity and mortality in neonates mostly in
developing, countries. Neonatal sepsis requires rapid and accurate diagnosis as well as
treatment for the improved outcome .. So an effective, simple clinical prediction tool is needed for the treatment decision. Our study was accomplished to analyze various Hematological parameters of sepsis and in combination to formulate a guideline for the digonis neonatal sepsis. The study was done in the special care neonatal unit (SCANU) of the ICH (Institute of child health) and (Shishu sasthya foundation) hospital, Mirpur a period of one year commencing from July 2009 to May 2010. A total of 43 neonates were taken who were suspected of neonatal septicemia. Blood samples for culture were taken before starting antibiotic therapy. Data on demographic characteristics mothers children's laboratory tests, results of blood cultures were collected. The results of the study showed that 53% patients were male and 43% patients were female. The ratio of male to female was 1.15: L Out of 32 neonates 3 (9 %) had positive blood culture for Pseudomonas and Streptococcus species. Thus there were only 3 cases of proven sepsis. Out of 43 Leucopenia (26 %), neutropenia (12%) neutrophilia (14%), leukocytosis (2%), and (12%) were observed in neonates with septicemia. Among 19 patients, CRP test was positive in 7 (37%) cases. The result of the study showed that C RP test is the significant parameters for diagnosis neonatal septicemia. So C RP test should be used diagnostic evaluation of the neonates with suspected sepsis as it is a very good test for the early detection of septicemia.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
