Abstract:
Polygonum hydropiper, Coccinia grandis and Litsea glutinosa are common
plants in Bangladesh. It has been reported to Coccinia grandis have medicinal
activities like hypoglycemic, antibacterial, antifungal and Litsea glutinosa used
for used as demulcent for ulcer; also for dysentery. The leaf of Polygonum
hydropiper plant has shown cytotoxic and thrombolytic activity. In this study,
extracted mixture from Polygonum hydropiper, Litsea glutinosa and Coccinia
grandis, were studied for antibacterial, thrombolytic, cytotoxic and scavenging
activity by using in vitro techniques. Analgesic activity was tested using in vivo
techniques. Ethanol extract of the plants were tested for Antibacterial activity
using disc diffusion method. Ethanolic extract of the plants were tested for brine
shrimp lethality bioassay using brine shrimp nauplii. The LC50 of ethanol
extract of Polygonum hydropiper extract was found to be 6.02μg/ml indicates
that extracts have good pharmacological action. The ethanol extract of the
extracts were also tested for in vitro thrombolytic activity. The extract showed
reasonable thrombolytic activity. Litsea glutinosa showed very good analgesic
activity having percent inhibition of writhing about 76.65. Coccinea grandis has
extremely good scavenging activity having the IC50 of 1.67μg/ml. Further
investigation on the plant is required to confirm their pharmacological activity
and thereby utilizing them as useful medicinal plant.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) of East West University, Dhaka, Bangladesh.