Abstract:
DHATRI LAUHA is a widely used formulation in folk and ayurvedic systems of
medicine and it is commonly used for Sularoga (colic), pandu (anaemia) , kamala
(jaundice), amlapitta (hyperacidity non ulcer dyspepsia). This ayurvedic drug mainly
formulated of Dhatri (amalaki) cuma, Lauha cuma (bhasma), Yastimadhuraja (cuma),
Amrta kvatha and these compounds are already well tested for their various types of
therapeutic action and in certain diseases. In addition to mixture of these compound
taken with ghee and honey for their optimum therapeutic activity. Total 9 experiments
were carried out at different doses (100, 200 and 400 mg/kg, p.o.) of DHATRI
LAUHA which studied in different animal model to find out the various degrees of
significance of action of the drug on experimental animals. Highly significant
(p=0.009) increase in ambulation behavior was observed in Hole board test. In Hole
cross test highly significant (p=0.005) increase in motor activity was observed. Open
field test showed significant (p=0.036) increase in Standing up behavior. Climbing
out test produced a significant (p=0.039) decrease in activity. None of the other
experiments resulted in significant observations but there have been overall decreases
or increases in activities in different experiments in comparison to respective control
groups.
All these experiment were executed in an attempt to confirm the safety of the general
patients or users of the society and country as a whole. After completion of this
research work now we can suggest that this DTR can be prescribed for treating
different diseases without or with a minimal central nervous system side-effect. It also
found that the drug has no effect on the gut motility and gastric emptying time.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
