Evaluation of Anti-ulcerant Effect of Oroxylum Indicum in Ulcerative Rat Model at Low Dose

Abstract

The medicinal plants signify a massive basis of potential phytoconstituents that could be valuable as a substitute to allopathic drugs or considered as an analogue in drug development. Oroxyllum indicum is one of the medicinal plants that show anticancer, anti-ulcer, anti-dysenteric, antimicrobial, and anti-inflammatory activity. Various part of this plant is used in medical purpose. Alkaloids, glycocides, terpinoids, steroids, flavanoids, phenolics, tannins, anthraquinone, Coumarins etc. component has been found in this plant extract that show different therapeutic effects. In this project we investigated the methanolic extract of bark of Oroxyllum indicum for anti-ulcer activity. To identify the plants therapuetic effects we conducted anti-ulcer and histopathology tests. The anti-ulcer activity of methanol extract of O.indicum bark was evaluated as dose of 100 mg/kg p.o while using omeprazole (20mg/kg,p.o) as the standard drug. Ulcer was induced by feeding 25ml/kg of ethanol (0.3M HCL in 60% ethanol). Gastric mucosa from the different groups were examined for ulcers by magnifying lens and scroring ulcer. For this experiment Swiss albino rats were used. O.indicum is moderately significant (P< 0.01) in protection of ethanol-induced ulcer, it showed protection of 65% at dose 100 mg/kg/day, p.o as Omeprazol (standard drug) showed protection of 77%.. This findings was further supported by the histological study. The investigation suggests that low dose of methanolic extract of O.indicum bark possess moderate anti-ulcer activity.