dc.contributor.author |
Rabbi, Md. Fazlay |
|
dc.date.accessioned |
2017-06-13T04:17:25Z |
|
dc.date.available |
2017-06-13T04:17:25Z |
|
dc.date.issued |
12/22/2016 |
|
dc.identifier.uri |
http://dspace.ewubd.edu/handle/2525/2229 |
|
dc.description |
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh |
en_US |
dc.description.abstract |
The aim of the present study was to evaluate and compare dissolution pattern of locally
branded drug products of Metformin Hydrochloride available in Bangladesh with each
other. Glucophage® is the patent drug of Metformin Hydrochloride. Branded drugs are
expensive than locally marketed drug. Substitution of drugs is very essential for the
people of under developing country. Three different brands of Metformin Hydrochloride
tablets which are available in Bangladesh like Glucomet, Daomina and Met were
collected from a reputed pharmacy store. Six tablets from each of the brands were used
for the in-vitro dissolution study. Cumulative drug release was measured up to 50
minutes for all the brands. All the brands were compared with each other. Differential
factor, f1 and similarity factor, f2 were determined. Few differences were observed
during in-vitro drug release pattern of brand Glucomet, Met and Daomin with each other.
Significant differences were found between Glucomet and Met and also between
Glucomet and Daomin. The values of f1 found are respectively 27.51 and 28.52. And it
is not acceptable. The values of f2 found are respectively 26.76 and 26.2. And it is also
not acceptable. On the other hand, significant similarities were found between Met and
Daomin. In conclusion, further investigations are needed to evaluate better dissolution
study. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.publisher |
East West University |
en_US |
dc.relation.ispartofseries |
;PHA00559 |
|
dc.subject |
Metformin HCl, Comparative dissolution, In-vitro drug dissolution study |
en_US |
dc.title |
In-vitro Comparative Dissolution Study of Different Brands (Glucomet, Met and Daomin) of Metformin Hydrochloride Tablets Available in Bangladesh |
en_US |
dc.type |
Thesis |
en_US |