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In-vitro Comparative Dissolution Study of Different Brands (Glucomet, Met and Daomin) of Metformin Hydrochloride Tablets Available in Bangladesh

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dc.contributor.author Rabbi, Md. Fazlay
dc.date.accessioned 2017-06-13T04:17:25Z
dc.date.available 2017-06-13T04:17:25Z
dc.date.issued 12/22/2016
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2229
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh en_US
dc.description.abstract The aim of the present study was to evaluate and compare dissolution pattern of locally branded drug products of Metformin Hydrochloride available in Bangladesh with each other. Glucophage® is the patent drug of Metformin Hydrochloride. Branded drugs are expensive than locally marketed drug. Substitution of drugs is very essential for the people of under developing country. Three different brands of Metformin Hydrochloride tablets which are available in Bangladesh like Glucomet, Daomina and Met were collected from a reputed pharmacy store. Six tablets from each of the brands were used for the in-vitro dissolution study. Cumulative drug release was measured up to 50 minutes for all the brands. All the brands were compared with each other. Differential factor, f1 and similarity factor, f2 were determined. Few differences were observed during in-vitro drug release pattern of brand Glucomet, Met and Daomin with each other. Significant differences were found between Glucomet and Met and also between Glucomet and Daomin. The values of f1 found are respectively 27.51 and 28.52. And it is not acceptable. The values of f2 found are respectively 26.76 and 26.2. And it is also not acceptable. On the other hand, significant similarities were found between Met and Daomin. In conclusion, further investigations are needed to evaluate better dissolution study. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00559
dc.subject Metformin HCl, Comparative dissolution, In-vitro drug dissolution study en_US
dc.title In-vitro Comparative Dissolution Study of Different Brands (Glucomet, Met and Daomin) of Metformin Hydrochloride Tablets Available in Bangladesh en_US
dc.type Thesis en_US


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