Abstract:
The drug discovery process is not a predefined series of steps. Modern approaches include
target-based drug discovery in which researchers need to survey genetic profile like never before.
Genomics, particularly high‐throughput sequencing and characterization of expressed human
genes, has created new opportunities for drug discovery. Knowledge of all the human genes and
their functions may allow effective preventive measures, and change drug research strategy and
drug discovery development processes. Pharmacogenomics is the application of genomic
technologies such as gene sequencing, statistical genetics, and gene expression analysis to drugs
in clinical development and on the market. It applies the large‐scale systematic approaches of
genomics to speed the discovery of drug response markers, whether they act at the level of the
drug target, drug metabolism, or disease pathways. The two most important needs for this type of
technology are to find more effective biomarkers for disease detection and discover gene to
which therapeutic drugs can be targeted. It is well-known that the risks are high in drug
discovery process and there are long timelines to be passed before it is known whether a
candidate drug will succeed or fail. Making accurate decisions within an accelerated process is
the key to success to the pharmaceutical companies.
Genomics revolution had a very positive impact upon these issues and now proteomics is in the
field as a powerful new partner of genomics. Each step of the process from target discovery to
clinical trials is accessible to genomics. Scientists are able to see every dimension of their
biological focus, from genes, mRNA, proteins and their sub cellular localization. This will
greatly assist our understanding of the fundamental mechanistic basis of human disease and will
allow discovery of improved, speedier, less toxic and hopefully, inexpensive drugs.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh.