Abstract:
The plant Mentha arvensis has been used for the general promotion of health and
longevity by Asian tribal. It is used as a traditional medicine for the treatment of various
diseases like asthma, piles, diarrhea etc. The aim of the present study was to evaluate the cytotoxicity activity, and antioxidant activity of pet-ether extract of Mentha arvensis. The
powdered leaves of Mentha arvensis were extracted with methanol and then partitioned
with pet-ether, ethyl acetate and dichloromethane consecutively. The pet-ether fraction
was used to evaluate cytotoxic, and antioxidant activities. The cytoxic activity was
measured by brine shrimp lethality bioassay. Pet-ether fraction showed cytotoxic activity
with LC50 value 17.79μg/ml in brine shrimp lethality test. The fraction contained
12.315mgAAE/g of total phenolic content and 56mg AAE/g total flavonoid content and
27.5mg AAE/g total reducing power content. The results of study clearly indicate the
presence of cytotoxic, and antioxidant properties of pet-ether extract. The obtained results
provide a support for the use of this plant in traditional medicine and its further
investigation.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh