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In-vitro Comparative Dissolution Study of Different Brands of Ranitidine Hydrochloride Tablets Available in Bangladesh

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dc.contributor.author Hossain, Md. Kabir
dc.date.accessioned 2016-09-21T03:13:08Z
dc.date.available 2016-09-21T03:13:08Z
dc.date.issued 5/17/2016
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/1815
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh en_US
dc.description.abstract The aim of the present study was to evaluate and compare dissolution pattern of locally branded drug products of Ranitidine HCl available in Bangladesh with the innovator brand of Ranitidine HCl (Zantac) marketed by GSK pharmaceutical company. Zantac® is the patent drug of ranitidine hydrochloride. Branded drugs are expensive than locally marketed drug. Substitution of drugs is very essential for the people of under developing country. Two different brands of ranitidine tablets which are available in Bangladesh like Neotack, Ranidin as well as Zantac® were collected from a reputed pharmacy store. Six tablets from each of the brands were used for the in-vitro dissolution study. Cumulative drug release was measured up to 50 minutes for all the brands. All the brands were compared with the innovator brand. Differential factor, f1 and similarity factor, f2 were determined. No significant difference was observed during in-vitro drug release pattern of brand Neotack and Ranidin with the innovator brand. Here it was found the values of f1 are 13.19 and 13.41 so it is acceptable. And the similarity factor it was seen that the values of f2 are 51.8 and 50.2, so it is acceptable. In conclusion, further investigations are needed to evaluate better dissolution study. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00458
dc.subject Ranitidine HCl, Generic brand, Innovator drug product, Comparative dissolution, In-vitro drug dissolution study en_US
dc.title In-vitro Comparative Dissolution Study of Different Brands of Ranitidine Hydrochloride Tablets Available in Bangladesh en_US
dc.type Thesis en_US


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