Study of Pharmacological activities of methanolic extract of hydnocarpus kurzii bark

Abstract

The research work was carried out to determine the pharmacological activities of methanolic extract of Hydnocarpus Kurzii Bark. Methanolic bark extract was administered orally to the animal model (Swiss albino) and the effects were determined by comparing with respect to control group which were treated with 5% CMC. For every experiment positive control was used. Different experiments were used to determine the pharmacological profile which was Collected from internationally published publications and journals. CNS depressant drugs used in clinically worldwide. So I focus to find out the CNS activity of Hydnocarpus Kurzii. The CNS activity was evaluated by open field method and hole board test. In the open field method and hole board experiment the crude extract of Hydnocarpus Kurzii. (200mg/kg, 400mg/kg & 800mg/kg) dose dependently reduces the number of peripheral locomotion, central locomotion and leaning in the open field test and reduces the number of head dipping and head poking in the hole board test. The reduction is significant (***p<0.001) when it is compared to the standard drug. The Laxative Effect was evaluated by Charcoal meal GI transit test where methanolic extract at dose of 800 mg/kg body weight increase the charcoal transit which compare with positive control. The aim of the study was also to investigate the possible toxicity of the plant Hydnocarpus Kurzii and especially to establish the safety of the methanolic extract of this plant by focusing on its acute and chronic toxicity in mice. For finding chronic toxicity several tests are done such as CBC (Cell Blood count) test, Hepatic enzyme test and histopathological Studies. All data were analyzed by using SPSS analytical method. After summarize all the results it can say that bark of Hydnocarpus Kurzii may have several pharmacological activities but to prove the hypothesis it need further higher studies.