Determination of variation in flow property of different formulas of polyethylene Glycol along with Amlodipine and Propranolol

Abstract

The objective of this research project was to evaluate the flow property of different sets of Formulas of Amlodipine and Propranolol along with PEG (Polyethylene Glycol) individually and in combination as well. Here we tried to focusing to isolate a specific equation which explain the flowability of a formulation.we had measured several parameters, such as, bulk density, tapped density, Carr’s index, Hausner’s ratio and angle of repose for different mixture of same pharmaceutical recipients but in different ratio. For accurate result the experiments were done four times and all the guidelines were followed. By evaluating the laboratory experimental data, we were able to determine several specific equations (y= mx + c) for particular mixtures of specific pharmaceutical excipients. My work was based on the variation in flowability of mixtures due to the presence of different amount of binders. Flow property of pharmaceutical excipients for a new drug formulations can be predicted and measured by these equations