Thesis 2016

Linagliptin Prescription in Frequency as Antidiabetic Drug

Thu, 28 Jan 2016 00:00:00 GMT

Linagliptin Prescription in Frequency as Antidiabetic Drug Azad, Farhana This retrospective study was designed to observe the adherence of the new antidiabetic drugs prescribing practice in diabetic hospital of our country. During two months study period, 500 prescription (Diabetic Books prescription and new patients initial form prescription) suffering from diabetes mellitus were enrolled from the BIRDEM, Shahabag, Dhaka. This research revealed that insulin alone or in combination with metformin or alone metformin or alone vildagliptin, sitagliptin, linagliptin or metformin in combination with vildagliptin, sitagliptin, linagliptin and other types of drugs which were prescribed for the treatment of patient suffering from diabetes. Our study found only 19 prescriptions with linagliptin among 500 prescriptions which was only 3.8%. So it can be calculated that linagliptin still seems to be not well accepted by most of the physicians. Another outcome of this study indicated that in 42% prescription there is a practice of old antidiabetic drugs. Furthermore, county wide multicenter research with a large sample is still needed to consolidate the observation of this study. This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh.

Study of Pharmacological Activities of Methanolic Extract of Phyla Nodiflora

Sun, 01 Jan 0002 00:00:00 GMT

Study of Pharmacological Activities of Methanolic Extract of Phyla Nodiflora Hossen, Md. Firoz Purpose: The research work was carried out to determine the pharmacological activities of methanolic extract of Phyla Nodiflora. Method: Methanolic extract was administered orally to the animal model (Swiss albino) and the effects were determined by comparing with respect to control group which were treated with 5% CMC. For every experiment positive control was used. Different experiments were used to determine the pharmacological profile which was Collected from internationally published publications and journals. Result: The Laxative Effect was evaluated by Charcoal meal GI transit test where methanolic extract at dose of 800 mg/kg body weight increase the charcoal transit which compare with positive control. The CNS activity was evaluated by open field method and hole board test. In the open field method and hole board experiment the crude extract of Phyla Nodiflora. (200mg/kg,400mg/kg & 800mg/kg) dose dependently reduces the number of peripheral locomotion, central locomotion and leaning in the open field test and reduces the number of head dipping and head poking in the hole board test. The reduction is significant (***p<0.001) when it is compared to the standard drug. The aim of the study was also to investigate the possible toxicity of the plant Phyla Nodiflora and especially to establish the safety of the methanolic extract of this plant by focusing on its acute and chronic toxicity in mice. Conclusion: After summarize all the results it can say that Phyla Nodiflora may have several pharmacological activities but to prove the hypothesis it need further higher studies. Keywords: This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh.

Insecticidal effects of Stephania japonica L. on pulse beetle (Callosobruchus chinensis L.),rice weevil (Sitophyllus oryzae L.) and Mosquito larvae

Sun, 01 Jan 0002 00:00:00 GMT

Insecticidal effects of Stephania japonica L. on pulse beetle (Callosobruchus chinensis L.),rice weevil (Sitophyllus oryzae L.) and Mosquito larvae Ahmed, Farhana An insecticide is a substance used to kill insects.They include ovicides and larvicides used against eggs and larvae,respectively.Insecticides are used in agriculture, medicine, industry and by consumers. Insecticides are claimed to be a major factor behind the increase in agricultural 20th century's productivity. Nearly all insecticides have the potential to significantly alter ecosystems; many are toxic to humans; Insecticides can be classified in two major groups as systemic insecticide which have residual or long term activity and contact insecticides, which have no residual activity.Experiments were conducted in the laboratory to study the efficacy of Stephania Japonica L. for the control of rice weevil (Sitophilus oryzae L. ) in the storage, pulse beetle( Callosobruchus chinensis L..) in the storage and larvae of mosquito. The efficacy of Stephania Japonica was assessed on the basis of Screening test,repellent test, grain soak test, direct toxic and surface contact effects of rice & pulse grains.Extracts were made using solvents such as acetone,ethanol and water. The extract was used in three doses at 1 mg, 5 mg and 10 mg. The higher doses of Stephania Japonica L. gave better result. The effect of Staphania Japonica on insecticides of direct toxicity, repellency, grain soak and surface contact effects were found directly proportional to the level of concentration. It was observed from the results that the plant extract had significant repellent and screening effect, surface contact effect, and grain soak effect. Mortality percentage was found to vary among different concentrations of plant extracts. The highest mortality was observed with highest concentrations of Stephenia japonica L. This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh.

Studies on the Antioxidant, Thrombolytic activity and Laxative effect activity of methanolic extracts of the Stephania Japonica and Trapa Bispinosa Plants

Fri, 01 Jan 0012 00:00:00 GMT

Studies on the Antioxidant, Thrombolytic activity and Laxative effect activity of methanolic extracts of the Stephania Japonica and Trapa Bispinosa Plants Uddin, Mohammad Zia A medicinal plant is a plant that has similar properties as conventional pharmaceutical drugs. Humans have used them throughout history to either cure or lessen symptoms from an illness. A pharmaceutical drug is a drug that is produced in a laboratory to cure or help an illness.Nature always stands as a golden mark to exemplify the outstanding phenomena of symbiosis. Natural products from plant, animal and minerals have been the basis of the treatment of human disease (Verma et al., 2008). Plants have been a major source of therapeutic agents since time immemorial. The increasing acceptance of traditional herbal systems of medicine in the world has resulted in the revival of ancient traditions of medicine. Medicinal plants and their derivatives are thus looked upon not only as a source of affordable healthcare but also as an important commodity item of international trade and commerce This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh.