http://dspace.ewubd.edu:8080/handle/123456789/2261 2026-04-05T23:50:46Z 2026-04-05T23:50:46Z Hossain, Tanjina http://dspace.ewubd.edu:8080/handle/123456789/2664 2019-03-13T07:46:19Z 0012-01-01T00:00:00Z

Identification Of Socio-Demographic And Behavioral Risk Factors Of Oral Cancer In Rural And Urban Areas Of Bangladesh Hossain, Tanjina Abstract: This study was conducted as a cross sectional survey in the National Institute of Cancer Research and Hospital, Dhaka Bangladesh. A questionnaire was designed and comprised of relevant questions to determine socio-demographic information, awareness and knowledge of oral cancer and risk factors and questions on participant’s exposure to risk factors were also included. Method: Subjects above the age of 30 years (n=114) were randomly selected during the period from 1 June 2016 to October 2017. The questionnaire was distributed to complete while they were waiting for their treatment at the National Institute of Cancer Research and Hospital (NICRH). Data was analyzed using Microsoft Excel 2010 and statistical package Result: The study revealed that, female adult was more susceptible to oral cancer than male. The mean age of the participants was 48.7 ± 10.8 years ranging from 30 to 85. Among the 114 patients, 85% came from rural areas and 69% of those population found illiterate. From the study we found that, tobacco smoking, smokeless tobacco (betel leaf, betel nut, quid chewing, jorda, gull) and alcohol was the major risk factors of oral cancer. Also, sun or radiation exposure and fungal infection was identified as a risk factors of oral cancer. In this study, we also found that local factor such as faulty teeth, sharp teeth, loose teethe and denture are important factor for oral cancer. As a sign and symptom, non-healing mouth ulcer and Lump in neck could be major signs of oral cancer. Among these all cancer patients, 38.6% were affected in buccal mucosa, 25.44% were affected in alveolar region and few of them are in lip (14.04%). The study shows that TNM stage of most patients were T2N1Mx, T2N3Mx that means tumor size 2 to 6 cm and cancer cell present in lymph node and metastasis information could not be assessed. Our study about chemotherapeutic treatment indicate that 5-flurouracil, Paclitaxel, Cisplatin and Carboplatin are most commonly use in Oral Cancer. Conclusion: At current circumstance, all through the world and our nation, number of oral cancer patient increased day by day. Respondents were found having a low level of knowledge scores on the risk factor, sign and symptoms, diagnosis and treatment of oral cancer. The present investigation primarily gives a thought that there might be some connection between oral cancer and different risk factors. This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh.

0012-01-01T00:00:00Z Haque, Mahjabin http://dspace.ewubd.edu:8080/handle/123456789/2643 2019-03-13T07:46:19Z 0011-01-01T00:00:00Z

Compatibility Study of Albendazole, Levofloxacin and Pregabalin with Various Excipients and their Subsequent Formulation Optimization Haque, Mahjabin This work was proposed to assess the compatibility of Actives viz. Albendazole, Levofloxacin and Pregabalin with different functional excipients like fillers/diluents, disintegrants, binders and lubricants which are commonly used in solid dosage formulation. Samples were made by mixing active and excipients in different ratio and put in stability chamber at different stability conditions. Samples were withdrawn at different time intervals and tested accordingly. Assay, Impurity and IR spectrum were chosen as testing parameter to determine the compatibility of actives with particular excipient. This research work has demonstrated the relationship between active and excipients and their compatibility in dosage form formulation. Tentative formula of the dosage forms viz. Albendazole Chewable Tablets, Levofloxacin Film Coated Tablets and Pregabalin Capsules were also established and evaluated. This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh.

0011-01-01T00:00:00Z Tajrin, Taniza http://dspace.ewubd.edu:8080/handle/123456789/2641 2019-03-13T07:46:19Z 0011-01-01T00:00:00Z

Depth Profiling of Penetration of Niacinamide into the Stratum Corneum: Effect of Hydration and Oil massage Tajrin, Taniza Niacinamide is a cosmetic compound that is used in many cosmetic formulations nowadays due to its skin care properties. The present study was designed for the depth profiling of penetration of niacinamide into the skin using a control formulation. In addition, since proper amount of niacinamide penetration is necessary for skin benefit, influence of two external factors, such as skin hydration and oil massage on the penetration of niacinamide was investigated. For this study an international face cream brand was used as a test sample and the formulation was applied to eleven healthy volunteer on different sites of right and left volar forearm. The volunteers were aged between 18to 27 years. The calibration curve was formed by range of 5μg/mL to 30μg/mL. The calibration curve was found to be linear (R2>0.999). This study is conducted by tape-striping process where stratum corneum of skin was removed and amount of niacinamide content in per tape were analyzed by using UV-Spectroscopy at 262nm wavelength. The depth profile of niacinamide from control site was compared with the skin hydration and oil massaged sites. No significant difference was observed in the amount of niacinamide at any depth of skin from control to hydration or oil massage (p>0.05). In addition, the analysis was extended to observe if there any difference between male and female skin. However, like the general result, male and female skin was also failed to show any significant influence of skin hydration and oil massage in penetrating niacinamide (p>0.05). The skin was hydrated or massaged with oil for only 2 minutes. The time may not be sufficient to show any significant difference. IV This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh.

0011-01-01T00:00:00Z Jahan, Nusrat http://dspace.ewubd.edu:8080/handle/123456789/2640 2019-03-13T07:46:19Z 0012-01-01T00:00:00Z

A Descriptive Study on Use of Fixed Dose Combination (FDC) Tablets and Role of DOT in TB Treatment Jahan, Nusrat Tuberculosis (TB) is a major public health problem worldwide and Bangladesh is one of the high burden countries with high incidence and prevalence rates. Fixed dose combinations (FDC) is recommended for any type of TB cases in order for the patient to completely get cure from the disease. The role of Directly Observed Treatment (DOT) is an important factor to ensure the proper dosage and time of treatment. In order to determine the use of FDC tablets for TB treatment and the role of DOT for effective tuberculosis control program, a descriptive study was carried out in Kanaighat Upazilla of Sylhet, Bangladesh. After taking written consent, a total of 50 TB patients, registered in Kanaighat health complex, were interviewed using a standard questionnaire. Detail information regarding the patients` course of treatment were recorded from their treatment cards preserved in the health complex. In-depth data analysis were done using the software SPSS, version 19. In our study, most of the patients (34%) infected with tuberculosis were in between 50-65 years. Majority of the cases were smear positive (54%), whereas 36% cases were smear negative. All patients in our study were treated with Category 1 and DOT followed. The results have shown that the sputum conversion rate was higher among those who had taken the drugs following DOT (75%). About 86% of all the patients enrolled in our study had followed their treatment regimen under DOT. About 90.5% of the patients with smear positive cases were declared as cured after completion of their treatment course. The use of FDC has benefited the patients when the dosage regimen of these tablets were prescribed according to weight and consumed under supervision of a DOT provider. The result of this study has shown that a very good outcome was obtained when patients get treated with anti-TB drugs as FDC and the need for DOT to improve the outcome of the patient This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh.

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